News
The World of EGF, Skin Renewal, and Feeling Like Yourself
1. The Nobel Prize Discovery That Put EGF on the Scientific Map
In 1986, scientists Stanley Cohen and Rita Levi-Montalcini received the Nobel Prize in Physiology or Medicine for their discoveries of growth factors. Cohen's work included the discovery of Epidermal Growth Factor, or EGF, helping scientists better understand how cells communicate and how growth is regulated. It is a remarkable chapter in scientific history - but an important distinction remains: the Nobel Prize recognised the discovery of growth factors, not any modern cosmetic serum. For us, that history is a reason to stay curious, not a reason to make miracle claims.
🔗 The Nobel Prize in Physiology or Medicine 1986 - Official Press Release
2. What the Research Really Says About Topical Growth Factors
A 2023 systematic review examined 33 studies involving 1,180 people and 23 different topical growth-factor preparations. The researchers found generally positive but modest improvements in areas such as skin texture, fine lines and overall facial appearance, with relatively few reported adverse events. They also highlighted important limits: the formulas, study designs and ways of measuring results varied widely, and only nine studies used a placebo or active comparison. The honest takeaway is encouraging but measured - topical growth factors are promising, yet every formula should be judged on its own evidence.
3. The Early EGF Serum Study Worth Understanding
One frequently referenced study followed 29 women aged 39 to 75 as they used a barley-produced, human-like EGF serum twice daily for three months. Researchers reported improvements in the visible signs they assessed, including texture, fine lines and the appearance of photodamage. However, it was a small, open-label study conducted at a single centre, with no placebo group. That means its findings are interesting, but they should not be treated as proof that every EGF serum will perform in the same way. The source, concentration, stability, supporting ingredients and complete formulation all matter.
4. Why No EGF Serum Replaces Daily Sun Protection
The most thoughtful skincare routine is built on the basics. Cancer Council Australia advises using sun protection when the UV Index reaches 3 or above and notes that regular sunscreen use helps protect against sun spots and premature ageing, as well as skin cancer. An EGF serum can be part of a routine designed around smoother, brighter and more rested-looking skin, but it cannot undo ongoing UV exposure or replace broad-spectrum sunscreen, protective clothing, a hat, shade and sunglasses. Healthy-looking skin begins with protecting the skin you already have.
🔗 Sunscreen Fact Sheet - Cancer Council Australia
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At Lerro, we believe good skincare education should leave you feeling informed, not overwhelmed. We will continue sharing the science behind EGF, the realities of topical skincare, and the everyday habits that help you care for your skin with confidence.